Reactome | RAC2 GEFs activate RAC2

RAC2 GEFs activate RAC2

Stable Identifier

R-HSA-9014296

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The following guanine nucleotide exchange factors (GEFs) were shown to bind RAC2 and catalyze GDP to GTP exchange on RAC2, resulting in formation of the active RAC2:GTP complex:
ABR (Chuang et al. 1995)
BCR (Chuang et al. 1995)
DEF6 (Mavrakis et al. 2004)
DOCK2 (Sai et al. 2008; Kwofie and Skowronski 2008 )
MCF2 (Jaiswal et al. 2013)
PREX1 (Welch et al. 2005; Dong et al. 2005; Barber et al. 2007; Jaiswal et al. 2013)
TIAM1 (Haeusler et al. 2003; Niebel et al. 2013; Jaiswal et al. 2013)
TRIO (Newsome et al. 2000; Hakeda-Suzuki et al. 2002; Jaiswal et al. 2013)
VAV1 (Ming et al. 2007; Miletic et al. 2007; Yin et al. 2011)
VAV2 (Arana et al. 2008; Jaiswal et al. 2013)
VAV3 (Flannagan et al. 2014)

The following GEFs are annotated as candidate RAC2 GEFs since they were shown to bind RAC2, but their ability to activate RAC2 has not been tested:
DOCK1 (Kwofie and Skowronski 2008)
DOCK3 (Kwofie and Skowronski 2008)
DOCK4 (Kwofie and Skowronski 2008)
DOCK10 (Ruiz-Lafuente et al. 2015)
SWAP70 (Sivalenka and Jessberger 2004)

The following RHO GEFs do not act on RAC2:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF4 (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9: (Kwofie and Skowronski 2008)
DOCK11 (Ruiz-Lafuente et al. 2015)
ITSN1 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
PLEKHG5 (De Toledo et al. 2001)

Literature References

PubMed ID	Title	Journal	Year
17060455	The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity Billadeau, DD, Li, S, Ming, W, Dinauer, MC, Quilliam, LA	Mol. Cell. Biol.	2007
17698854	Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase Welch, HC, Thelen, M, Anderson, KE, Donald, S, Barber, MA, Thelen, S	J. Biol. Chem.	2007
10847683	Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila Keleman, K, Newsome, TP, Debant, A, Dietzl, G, Schmidt, S, Asling, B, Dickson, BJ	Cell	2000
17214551	Asef is a Cdc42-specific guanine nucleotide exchange factor Ahmadian, MR, Gotthardt, K	Biol. Chem.	2007
18662984	Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis Sai, J, Raman, D, Richmond, A, Wikswo, J, Liu, Y	J. Biol. Chem.	2008
21151158	The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells Li, SY, Zhou, XL, Cao, YJ, Zhang, CZ, Du, MJ, Wan, YJ, Yin, J	Acta Pharmacol. Sin.	2011
11919634	Rac function and regulation during Drosophila development Luo, L, Harms, M, Dietzl, G, Nardine, T, Tzu, J, Sun, Y, Hakeda-Suzuki, S, Dickson, BJ, Ng, J	Nature	2002
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Ahmadian, MR, Jaiswal, M, Dvorsky, R	J. Biol. Chem.	2013
15542837	SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration Sivalenka, RR, Jessberger, R	Mol. Cell. Biol.	2004
16243036	P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils Li, Z, Mo, Z, Guo, C, Bokoch, G, Dong, X, Wu, D	Curr. Biol.	2005
11704860	The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3 Blangy, A, De Toledo, M, Schmidt, S, Coulon, V, Fort, P	Oncogene	2001
14675773	Comparative functional analysis of the Rac GTPases Blumenstein, L, Ahmadian, MR, Dvorsky, R, Haeusler, LC, Stege, P	FEBS Lett.	2003
15023524	DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA Jones, P, Sablitzky, F, McKinlay, KJ, Mavrakis, KJ	Exp. Cell Res.	2004
17158234	Vav proteins control MyD88-dependent oxidative burst Kloeppel, T, Swat, W, Fujikawa, K, Weaver, B, Brim, K, Graham, DB, Xavier, R, Schreiber, R, Montgrain, V, Miletic, AV	Blood	2007
16243035	P-Rex1 regulates neutrophil function Milne, LJ, Condliffe, AM, Jones, GE, Stephens, LR, Ferguson, GJ, Webb, LM, Welch, HC, Thelen, M, Coadwell, WJ, Hawkins, PT, Hill, K, Andrews, SR, Okkenhaug, K	Curr. Biol.	2005
18191593	Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation Batista, FD, Harwood, NE, Tybulewicz, VL, Vehlow, A, Henderson, R, Vigorito, E, Arana, E, Turner, M	Immunity	2008
7479768	Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family Heisterkamp, N, Xu, X, Bokoch, GM, Groffen, J, Kaartinen, V, Chuang, TH	Proc. Natl. Acad. Sci. U.S.A.	1995
25862245	Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells Moya-Quiles, MR, García-Serna, AM, Parrado, A, Sebastián-Ruiz, S, García-Alonso, AM, Alcaraz-García, MJ, Ruiz-Lafuente, N	Biol Open	2015
18056264	Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors Skowronski, J, Kwofie, MA	J. Biol. Chem.	2008
23757206	RNA-aptamers that modulate the RhoGEF activity of Tiam1 Wosnitza, CI, Famulok, M, Niebel, B	Bioorg. Med. Chem.	2013
24623723	The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis Furuya, W, Flannagan, RS, Grinstein, S, Glogauer, M, Canton, J	Mol. Biol. Cell	2014