Translation of ROBO3.2 mRNA is negatively regulated by NMD

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R-HSA-9014652
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Reaction [omitted]
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Homo sapiens
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Based on studies in mice, translation of ROBO3.2 mRNA in commissural axons at the floor plate is negatively regulated by nonsense mediated decay (NMD). Deficiency of NMD components results in aberrant axonal trajectories after crossing the midline (Colak et al. 2013).

Literature References
PubMed ID Title Journal Year
23746841 Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

Colak, D, Ji, SJ, Porse, BT, Jaffrey, SR

Cell 2013
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