Interleukin-36 pathway

Stable Identifier
R-HSA-9014826
Type
Pathway
Species
Homo sapiens
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Interleukin-36 alpha (IL36A), IL36B and IL36G are collectively known as IL36. They are members of the Interlukin-1 family that signal through a receptor composed of Interleukin-1 receptor-like 2 (IL1RL2, IL36R) and Interleukin-1 receptor accessory protein (IL1RAP, IL-1R/AcP) to promote inflammatory responses. Interleukin-36 receptor antagonist protein (IL36RN, IL36Ra) is a natural antagonist. IL36 is expressed predominantly by epithelial cells and is implicated strongly through functional and genetic evidence in the pathology of psoriatic disorders.

Literature References
PubMed ID Title Journal Year
25673295 Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions

Gabay, C, Towne, JE

J. Leukoc. Biol. 2015
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