Reactome | Me3K115-CALM1 [cytosol]

Me3K115-CALM1 [cytosol]

Stable Identifier

R-HSA-9016706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

triMe-K115-CALM1, Calmodulin, CALM_HUMAN

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)
        
        Me3K115-CALM1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0DP23 CALM1

Gene Names

CALM1, CALM, CAM, CAM1

Chain

initiator methionine:1, chain:2-149

Reference Genes

BioGPS Gene:801 CALM1

BioGPS Gene:805 CALM1

BioGPS Gene:808 CALM1

COSMIC (genes):CALM1 CALM1

CTD Gene:801 CALM1

CTD Gene:805 CALM1

CTD Gene:808 CALM1

dbSNP Gene:801 CALM1

dbSNP Gene:805 CALM1

dbSNP Gene:808 CALM1

ENSEMBL:ENSG00000198668 CALM1

HGNC:1442 CALM1

KEGG Gene (Homo sapiens):801 CALM1

KEGG Gene (Homo sapiens):805 CALM1

KEGG Gene (Homo sapiens):808 CALM1

Monarch:801 CALM1

Monarch:805 CALM1

Monarch:808 CALM1

NCBI Gene:801 CALM1

NCBI Gene:805 CALM1

NCBI Gene:808 CALM1

OMIM:114180 CALM1

Reference Transcript

Other Identifiers

0000130139

11724759_s_at

11724760_a_at

11724761_s_at

11749472_a_at

200653_s_at

200655_s_at

209563_x_at

211984_at

211985_s_at

213688_at

3548351

3548352

3548360

3548362

3548363

3548366

3548368

3548371

3548372

3548373

3548374

3548375

3548376

3548377

3983844

41143_at

41144_g_at

41288_at

51680_at

7976200

801

955_at

A_23_P163178

A_24_P313186

GE569065

GO:0000086

GO:0000165

GO:0000226

GO:0000278

GO:0000922

GO:0001975

GO:0002027

GO:0002376

GO:0002576

GO:0003013

GO:0003674

GO:0005509

GO:0005513

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005876

GO:0005886

GO:0005975

GO:0005980

GO:0006091

GO:0006464

GO:0006810

GO:0006936

GO:0007005

GO:0007010

GO:0007049

GO:0007165

GO:0007186

GO:0007190

GO:0007223

GO:0007267

GO:0008076

GO:0008092

GO:0008150

GO:0008179

GO:0009056

GO:0010800

GO:0010801

GO:0010856

GO:0010880

GO:0010881

GO:0016032

GO:0016192

GO:0016301

GO:0016310

GO:0019722

GO:0019855

GO:0019899

GO:0019901

GO:0019904

GO:0021762

GO:0022400

GO:0030017

GO:0030234

GO:0030235

GO:0030426

GO:0030672

GO:0031410

GO:0031432

GO:0031800

GO:0031954

GO:0031966

GO:0031982

GO:0031997

GO:0032465

GO:0032516

GO:0032991

GO:0034704

GO:0035307

GO:0038095

GO:0042592

GO:0043005

GO:0043167

GO:0043209

GO:0043226

GO:0043388

GO:0043539

GO:0043548

GO:0043647

GO:0044281

GO:0044325

GO:0044403

GO:0046872

GO:0047485

GO:0048306

GO:0048856

GO:0050998

GO:0050999

GO:0051000

GO:0051186

GO:0051301

GO:0051343

GO:0051412

GO:0051592

GO:0055085

GO:0055117

GO:0060314

GO:0060315

GO:0060316

GO:0061024

GO:0071902

GO:0072542

GO:0090150

GO:0090151

GO:0097718

GO:1900242

GO:1901841

GO:1901844

GO:1902494

GO:2000300

Hs.279009.6.A1_3p_at

ILMN_1778242

PH_hs_0023451

TC14000554.hg

g179809_3p_s_at

g5901911_3p_a_at

Participant Of

output

KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1

Other forms of this molecule

CALM1 [extracellular region]

CALM1 [plasma membrane]

CALM1 [nucleoplasm]

CALM1 [cytosol]

Inferred To

CALML3 [cytosol] (Gallus gallus)

Homologues of Me3K115-CALM1 [cytosol] (Caenorhabditis elegans)

Homologues of Me3K115-CALM1 [cytosol] (Dictyostelium discoideum)

Homologues of Me3K115-CALM1 [cytosol] (Drosophila melanogaster)

Homologues of Me3K115-CALM1 [cytosol] (Plasmodium falciparum)

CMD1 [cytosol] (Saccharomyces cerevisiae)

calm2 [cytosol] (Xenopus tropicalis)

cal-4 [cytosol] (Caenorhabditis elegans)

cal-3 [cytosol] (Caenorhabditis elegans)

mlcD [cytosol] (Dictyostelium discoideum)

Cam [cytosol] (Drosophila melanogaster)

Dmel\CG13898 [cytosol] (Drosophila melanogaster)

Me3K115-CALM1 [cytosol] (Caenorhabditis elegans)

Me3K115-CALM1 [cytosol] (Canis familiaris)

Me3K115-CALM1 [cytosol] (Dictyostelium discoideum)

Me3K115-CALM1 [cytosol] (Plasmodium falciparum)

Me3K115-CALM1 [cytosol] (Sus scrofa)

Acam [cytosol] (Drosophila melanogaster)

Calm3 [cytosol] (Rattus norvegicus)

calB [cytosol] (Dictyostelium discoideum)

cmd-1 [cytosol] (Caenorhabditis elegans)

calA [cytosol] (Dictyostelium discoideum)

cal-2 [cytosol] (Caenorhabditis elegans)

Calm1 [cytosol] (Mus musculus)

CALM [cytosol] (Bos taurus)

Dmel\CG30378 [cytosol] (Drosophila melanogaster)

cam1 [cytosol] (Schizosaccharomyces pombe)

Eip63F-1 [cytosol] (Drosophila melanogaster)

cal-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 115

Coordinate

115

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_001316851.1, NP_001734.1, NP_005175.2, NP_008819.1

OpenTargets

ENSG00000198668

GeneCards

P0DP23

HPA

ENSG00000198668-CALM1

Ensembl

ENSG00000198668, ENST00000356978, ENSP00000349467

PRO

P0DP23

PDB

4Q57, 2MG5, 5K8Q, 1YR5, 2LV6, 6CNN, 6MUD, 2Y4V, 1J7O, 1XFV, 6K4R, 1PK0, 5JTH, 3EWV, 2LQP, 2I08, 6B8L, 5COC, 3EWT, 2WEL, 3SUI, 1K93, 4Q5U, 5V03, 2KUH, 6JII, 2X0G, 2R28, 5GGM, 6FEG, 3DVE, 4V0C, 6FEH, 4OVN, 1XFW, 2K0E, 6K4L, 2BE6, 2F3Y, 6PBY, 1NKF, 2K0F, 4M1L, 1IWQ, 5WBX, 1XFU, 2N27, 6CNM, 6DAE, 6BUT, 4DCK, 2K61, 2M0J, 6DAF, 6E2G, 5V02, 1CDL, 3DVJ, 3J41, 5K7L, 2VAY, 6HCS, 6GDK, 1XFZ, 1ZUZ, 1SW8, 4L79, 5TP5, 5J8H, 6C1G, 6GDL, 3O77, 6JIU, 5I0I, 6B8P, 3G43, 5TP6, 4UMO, 6C1H, 1S26, 2HF5, 5DOW, 5DSU, 6B8Q, 3UCT, 1AJI, 2N6A, 1XFY, 2M55, 6JI8, 1UP5, 6N5W, 1J7P, 4JQ0, 4JPZ, 3DVM, 3DVK, 6CNO, 2V02, 2KUG, 1K90, 6MUE, 2V01, 3BYA, 2N77, 1WRZ, 6B8M, 5JQA, 1YRT, 6M7H, 5V7X, 2K0J, 2F3Z, 2LL6, 2L7L, 2W73, 4BYF, 1CLL, 6K4K, 4DJC, 6PBX, 4GOW, 2KNE, 2LGF, 1ZOT, 1XFX, 6O5G, 3OXQ, 4LZX, 2M0K, 5WC5, 4BW8, 4UPU, 6E2F, 2L53, 4BW7, 1L7Z, 1YRU, 6JRS, 6DAH, 1CTR, 5DBR, 1Y6W, 2LL7, 5OEO, 6EEB, 3O78, 1LVC, 2JZI, 6C1D, 2N8J, 3UCY, 6B8N, 1SK6, 6UZZ, 2LQC, 3UCW, 6V00, 6JV2, 6V01, 5J03, 3HR4, 6JIY, 6DAD

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.917	21
UniProt:O43303 CCP110	2	PolyUb-CCP110 [cytosol] (R-HSA-6783044) CCP110 [cytosol] (R-HSA-380261)	0.905	15
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.899	11
UniProt:P40136 cya	4	EF [extracellular region] (R-BAN-5205734) EF [cytosol] (R-BAN-5210957) EF [endosome membrane] (R-BAN-5210938) EF [plasma membrane] (R-BAN-5210924)	0.871	10
UniProt:Q15051 IQCB1	1	IQCB1 [cytosol] (R-HSA-5626648)	0.823	8
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.789	5
UniProt:O15078 CEP290	3	CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [extracellular region] (R-HSA-6806291) CEP290 [cytosol] (R-HSA-380275)	0.76	6
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.756	4
UniProt:O95259 KCNH1	1	KCNH1 [plasma membrane] (R-HSA-2291883)	0.715	4
UniProt:Q9WTI7-2 MYO1C			0.707	9
UniProt:Q9QXS1-3 PLEC			0.706	11
UniProt:Q92913-2 FGF13			0.704	4
UniProt:P51787-1 KCNQ1			0.695	6
UniProt:Q9UQM7 CAMK2A	6	CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.676	3
UniProt:Q9H0B3 IQCN			0.666	4
UniProt:O95259-2 KCNH1			0.655	8
UniProt:P53355 DAPK1	1	DAPK1 [cytosol] (R-HSA-418262)	0.65	6
UniProt:Q13557 CAMK2D	5	p-T287-CAMK2D [nucleoplasm] (R-HSA-444785) p-T287-CAMK2D [plasma membrane] (R-HSA-432794) p-T287-CAMK2D [endocytic vesicle membrane] (R-HSA-417002) CAMK2D [cytosol] (R-HSA-9611357) p-T287-CAMK2D [cytosol] (R-HSA-445370)	0.65	5
UniProt:Q6J8I9 MIP			0.623	2
UniProt:P27884 CAC1A			0.618	3
UniProt:P11233 RALA	2	RALA [cytosol] (R-HSA-170988) GGC-RALA [cytoplasmic vesicle membrane] (R-HSA-1458479)	0.593	3
UniProt:P11234 RALB	1	RALB [cytosol] (R-HSA-171015)	0.593	3
UniProt:Q99250 SCN2A	1	SCN2A [plasma membrane] (R-HSA-443377)	0.591	3
UniProt:P26645	2	Marcks [plasma membrane] (R-MMU-399985) phospho-Marcks [plasma membrane] (R-MMU-399989)	0.59	2
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [endosome membrane] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:O15554 KCNN4	1	KCNN4 [plasma membrane] (R-HSA-977543)	0.587	2
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.576	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P02686-5 MBP			0.558	2
IntAct:EBI-15728194 AQP0PEPTIDE			0.558	2
UniProt:Q07652	1	Cacna1e [plasma membrane] (R-RNO-210356)	0.558	2
UniProt:Q05152 CAC1B			0.558	2
UniProt:Q9HD67 MYO10	1	MYO10 [cytosol] (R-HSA-593679)	0.558	2
UniProt:A0JP07 A0JP07			0.556	3
UniProt:Q8NCR3 MFI			0.556	3
UniProt:P61088 UBE2N	5	Ub-C87-UBE2N [cytosol] (R-HSA-8864210) Ub-C87-UBE2N [nucleoplasm] (R-HSA-8943013) K63polyUb-C87-UBE2N [nucleoplasm] (R-HSA-6790511) UBE2N [nucleoplasm] (R-HSA-5682541) UBE2N [cytosol] (R-HSA-206072)	0.553	2
UniProt:P29274 ADORA2A	2	ADORA2A [plasma membrane] (R-HSA-418934) ADORA2A [Golgi membrane] (R-HSA-187668)	0.537	3
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	3
UniProt:Q96PM5 RCHY1	2	RCHY1 [nucleoplasm] (R-HSA-5655134) RCHY1 [cytosol] (R-HSA-976013)	0.524	2
UniProt:P61328-2 FGF12			0.524	2
UniProt:Q14318 FKBP8	2	FKBP8 [mitochondrial outer membrane] (R-HSA-5696928) PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001)	0.524	2
UniProt:Q9HCN6 GP6	1	GP6 [plasma membrane] (R-HSA-114574)	0.524	2
UniProt:Q9NWU2 GID8			0.508	2
UniProt:Q8WXU2 DAAF4			0.508	2
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.508	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.508	2
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	3
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.488	2
UniProt:P14416 DRD2	1	DRD2 [plasma membrane] (R-HSA-390816)	0.463	2
UniProt:Q03431 PTH1R	1	PTH1R [plasma membrane] (R-HSA-420479)	0.463	2

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