Gamma-secretase cleaves YBX1:NOTCH3

Stable Identifier
R-HSA-9017817
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Binding of NOTCH3 to YBX1 (YB-1) triggers cleavage of NOTCH3 by the gamma-secretase complex. The exact steps of YBX1-mediated NOTCH3 activation are not known. The gamma-secretase complex releases NOTCH3 intracellular domain (NICD3), leading to activation of NOTCH3 target genes downstream of YBX1 (Rauen et al. 2009).

Literature References
PubMed ID Title Journal Year
19640841 YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation

Rauen, T, Raffetseder, U, Frye, BC, Djudjaj, S, M├╝hlenberg, PJ, Eitner, F, Lendahl, U, Bernhagen, J, Dooley, S, Mertens, PR

J. Biol. Chem. 2009
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Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
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Activity
Orthologous Events
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