ESR1:ESTG and EP300 are recruited to TFF3 promoter

Stable Identifier
R-HSA-9018499
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TFF3 is an estrogen-responsive gene whose expression is primed prior to estrogen receptor binding by the formation of FOXA1- and GATA3-dependent chromatin loops. Interaction of ligand-bound ESR1 with the enhancer promotes recruitment of EP300 and other chromatin modifiying enzymes, and stimulates the deposition of active chromatin marks like H3K4 methylation and H3K27 acteylation (Laganière et al, 2005; Theodorou et al, 2013; reviewed in Zaret and Carroll, 2011)

Literature References
PubMed ID Title Journal Year
22056668 Pioneer transcription factors: establishing competence for gene expression

Zaret, KS, Carroll, JS

Genes Dev. 2011
16087863 From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response

Laganière, J, Deblois, G, Lefebvre, C, Bataille, AR, Robert, F, Giguère, V

Proc. Natl. Acad. Sci. U.S.A. 2005
23172872 GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility

Theodorou, V, Stark, R, Menon, S, Carroll, JS

Genome Res. 2013
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