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EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
Stable Identifier
R-HSA-9018569
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
EGFR phosphorylates NOTCH3 (Homo sapiens)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
NOTCH3 binds activated EGFR (Homo sapiens)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25125655
EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling
Huppert, SS
,
Carbone, DP
,
Arasada, RR
,
Rahman, MA
,
Amann, JM
Cancer Res.
2014
Participants
components
EGF:p-6Y-EGFR dimer [plasma membrane]
(Homo sapiens)
NICD3 [cytosol]
(Homo sapiens)
Participates
as an input of
EGFR phosphorylates NOTCH3 (Homo sapiens)
as an output of
NOTCH3 binds activated EGFR (Homo sapiens)
Inferred To
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
(Gallus gallus)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
(Mus musculus)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
(Rattus norvegicus)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]
(Xenopus tropicalis)
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