NOTCH3 binds activated EGFR

Stable Identifier
R-HSA-9018573
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The intracellular domain of NOTCH3 (NICD3) co-immunoprecipitates with ligand activated, autophosphorylated EGFR. Binding of NOTCH3 to EGFR is inhibited by erlotinib treatment, which prevents EGFR activation (Arasada et al. 2014).

Literature References
PubMed ID Title Journal Year
25125655 EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling

Arasada, RR, Amann, JM, Rahman, MA, Huppert, SS, Carbone, DP

Cancer Res. 2014
Participants
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Orthologous Events
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