Biosynthesis of D-series resolvins

Stable Identifier
R-HSA-9018676
Type
Pathway
Species
Homo sapiens
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The D-series resolvins (RvD1-6) are biosynthesised from the precursor ω-3 fatty acid docosahexaenoic acid (DHA), either via aspirin-triggered cylcooxygenase catalysis (17(R) AT-RvDs) or via the lipoxygenase pathway (described here) forming the epimeric 17(S)-RvD1-6 resolvins (Serhan et al. 2014, Bannenberg & Serhan 2010).

Literature References
PubMed ID Title Journal Year
25359497 Lipid mediators in the resolution of inflammation

Serhan, CN, Chiang, N, Dalli, J, Levy, BD

Cold Spring Harb Perspect Biol 2014
20708099 Specialized pro-resolving lipid mediators in the inflammatory response: An update

Bannenberg, G, Serhan, CN

Biochim. Biophys. Acta 2010
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