RHOQ binds effectors at the plasma membrane

Stable Identifier
Reaction [binding]
Homo sapiens
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Active GTP bound RHOQ binds to the following effectors at the plasma membrane:
ARHGAP33 (also known as TCGAP) (Chiang et al. 2003)
CDC42EP3 (also known as Borg2) (Joberty et al. 1999)
CDC42EP4 (also known as Borg4) (Joberty et al. 1999, Osada et al. 2000, Bagci et al. 2020)
IQGAP1 (Jacquemet and Humphries 2013)
PAK1 (Vignal et al. 2000; Bagci et al. 2020)
TRIP10 (Chang et al. 2002)

The following effectors were shown to bind to RHOQ in some but not all studies or have only reported in the high throughput screen by Bagci et al. 2020 and are annotated as candidates:
ARHGAP1 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARL13B (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42BPA (Bagci et al. 2020)
CDC42BPB (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CDC42EP2 (also known as Borg1) (RHOQ binding: Joberty et al. 1999, no RHOQ binding: Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
GFOD1 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
GJA1 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WIP WASP complex component WASL (RHOQ binding: Abe et al. 2003; no RHOQ binding: Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

RHOQ does not bind the following effectors:
ARFGAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
CDC42EP5 (also known as Borg3) (Joberty et al. 1999)
CDC42SE2 (Bagci et al. 2020)
FNBP1L (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
KCTD3 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
SH3PXD2A (Bagci et al. 2020)
SHKBP1 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
WDR81 (Bagci et al. 2020)
WDR91 (Bagci et al. 2020)
WIP WASP complex components WIPF1, WIPF2 and WIPF3 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)
Literature References
PubMed ID Title Journal Year
10490598 The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins

Joberty, G, Macara, IG, Perlungher, RR

Mol. Cell. Biol. 1999
12242347 The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes

Chang, L, Adams, RD, Saltiel, AR

Proc. Natl. Acad. Sci. U.S.A. 2002
12456725 Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

Kato, M, Takenawa, T, Miki, H, Endo, T, Abe, T

J. Cell. Sci. 2003
11185749 Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue

Suzuki, Y, Hashimoto, K, Kusuda, J, Sugano, S, Osada, N

J. Hum. Genet. 2000
24355937 IQGAP1 is a key node within the small GTPase network

Humphries, MJ, Jacquemet, G

Small GTPases 2013
12773384 TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport

Hwang, J, Legendre, M, Zhang, M, Saltiel, AR, Kimura, A, Chiang, SH

EMBO J. 2003
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
10967094 Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

Blangy, A, Gauthier-Rouvière, C, Vignal, E, De Toledo, M, Ladopoulou, A, Comunale, F, Fort, P

J. Biol. Chem. 2000
Orthologous Events
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