Reactome | RHOQ binds effectors at the plasma membrane

RHOQ binds effectors at the plasma membrane

Stable Identifier

R-HSA-9018746

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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RHOQ binds effectors at the plasma membrane

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Active GTP bound RHOQ binds to the following effectors at the plasma membrane:
ARHGAP33 (also known as TCGAP) (Chiang et al. 2003)
CDC42EP3 (also known as Borg2) (Joberty et al. 1999)
CDC42EP4 (also known as Borg4) (Joberty et al. 1999, Osada et al. 2000, Bagci et al. 2020)
IQGAP1 (Jacquemet and Humphries 2013)
PAK1 (Vignal et al. 2000; Bagci et al. 2020)
TRIP10 (Chang et al. 2002)

The following effectors were shown to bind to RHOQ in some but not all studies or have only reported in the high throughput screen by Bagci et al. 2020 and are annotated as candidates:
ARHGAP1 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARL13B (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42BPA (Bagci et al. 2020)
CDC42BPB (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CDC42EP2 (also known as Borg1) (RHOQ binding: Joberty et al. 1999, no RHOQ binding: Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
GFOD1 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
GJA1 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK4 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WIP WASP complex component WASL (RHOQ binding: Abe et al. 2003; no RHOQ binding: Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

RHOQ does not bind the following effectors:
ARFGAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
CDC42EP5 (also known as Borg3) (Joberty et al. 1999)
CDC42SE2 (Bagci et al. 2020)
FNBP1L (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
KCTD3 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
SH3PXD2A (Bagci et al. 2020)
SHKBP1 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
WDR81 (Bagci et al. 2020)
WDR91 (Bagci et al. 2020)
WIP WASP complex components WIPF1, WIPF2 and WIPF3 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
10490598	The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins Joberty, G, Perlungher, RR, Macara, IG	Mol. Cell. Biol.	1999
12242347	The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes Chang, L, Adams, RD, Saltiel, AR	Proc. Natl. Acad. Sci. U.S.A.	2002
12456725	Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth Abe, T, Kato, M, Miki, H, Takenawa, T, Endo, T	J. Cell. Sci.	2003
11185749	Sequence analysis, gene expression, and chromosomal assignment of mouse Borg4 gene and its human orthologue Osada, N, Kusuda, J, Suzuki, Y, Sugano, S, Hashimoto, K	J. Hum. Genet.	2000
24355937	IQGAP1 is a key node within the small GTPase network Jacquemet, G, Humphries, MJ	Small GTPases	2013
12773384	TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport Chiang, SH, Hwang, J, Legendre, M, Zhang, M, Kimura, A, Saltiel, AR	EMBO J.	2003
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
10967094	Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42 Vignal, E, De Toledo, M, Comunale, F, Ladopoulou, A, Gauthier-Rouvière, C, Blangy, A, Fort, P	J. Biol. Chem.	2000