RHOQ GEFs activate RHOQ

Stable Identifier
Reaction [transition]
Homo sapiens
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOQ and catalyze GDP to GTP exchange on RHOQ, resulting in formation of the active RHOQ:GTP complex:
ITSN1 (Jaiswal et al. 2013)
OBSCN (Coisy-Quivy et al. 2009)
PREX1 (Jaiswal et al. 2013)

ARHGEF9 was implicated as a RHOQ GEF by some (Papadopoulos et al. 2015) but not all (Jaiswal et al. 2013; Mayer et al. 2013) studies and is annotated as a candidate RHOQ GEF.

The following GEFs do not act on RHOQ:
AKAP13 (also known as Lbc) (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF2 (also known as GEF-H1) (Ren et al. 1998)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF4 (also known as Asef) (Gotthardt and Ahmadian 2007; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
DNMBP (Jaiswal et al. 2013)
MCF2 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)
TRIO (Jaiswal et al. 2013)
VAV2 (Jaiswal et al. 2013)
Literature References
PubMed ID Title Journal Year
24297911 Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission

Papadopoulos, T, Soykan, T, Ahmadian, MR, Brose, N, Jaiswal, M, Rhee, JS, Betz, H, Mayer, S, Kumar, R

Proc. Natl. Acad. Sci. U.S.A. 2013
25678704 Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability

Papadopoulos, T, Grubm├╝ller, H, Brose, N, Schemm, R

J. Biol. Chem. 2015
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Lehmann, D, Gan, X, Wang, P, Wang, Z, Li, L, Smrcka, AV, Iwasaki, A, Wu, D, Cohn, L, Kumamoto, Y

J. Biol. Chem. 2009
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Ahmadian, MR, Jaiswal, M, Dvorsky, R

J. Biol. Chem. 2013
9857026 Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

Busch, H, Zheng, Y, Li, R, Ren, Y

J Biol Chem 1998
7721814 Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

Olson, MF, Cerione, RA, Toksoz, D, Hall, A, Zheng, Y

J. Biol. Chem. 1995
17214551 Asef is a Cdc42-specific guanine nucleotide exchange factor

Ahmadian, MR, Gotthardt, K

Biol. Chem. 2007
21454492 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Cirstea, IC, Ahmadian, MR, Uhlenbrock, K, Jaiswal, M, Dvorsky, R, Gremer, L, Haeusler, LC

J. Biol. Chem. 2011
19258391 TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin

Fort, P, Philips, A, Bourret, A, Hipskind, RA, Mercier, J, Touzet, O, Coisy-Quivy, M

J. Cell. Sci. 2009
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOQ GEFs [cytosol]

Orthologous Events
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