Reactome | GDIs bind RHOH

GDIs bind RHOH

Stable Identifier

R-HSA-9018754

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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While RHOH is constitutively bound to GTP and not found in the GDP bound state, GDP dissociation inhibitors (GDIs), still interact with RHOH. GDIalpha, GDIbeta and GDIgamma bind to RHOH and presumably affect its translocation to the site of activity by sequestering it in the cytosol (Li et al. 2002). Binding of RHOH to RHO GDIs has been reported as weak (Fauré and Dagher 2001).

Literature References

PubMed ID	Title	Journal	Year
11809807	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function Flavell, RA, Lim, B, Avraham, H, Bu, X, Li, X, Lu, B	Mol. Cell. Biol.	2002
11368848	Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI) Fauré, J, Dagher, MC	Biochimie	2001