Reactome | RHOH binds effectors at the plasma membrane

RHOH binds effectors at the plasma membrane

Stable Identifier

R-HSA-9018758

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOH binds effectors at the plasma membrane

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RHOH plays an important role in development of T lymphocytes and binds to several kinases involved in T lymphocyte activation, including:
ZAP70 (Gu et al. 2006, Chae et al. 2010, Wang et al. 2011)
LCK (Chae et al. 2010, Wang et al. 2011)
CSK (Wang et al. 2010).

Additional RHOH interactors include:
PAK1 (Wang et al. 2010; Tajadura Ortega et al. 2018)
PAK2 (Tajadura Ortega et al. 2018)
PAK4 (Tajadura Ortega et al. 2018)
PAK5 (Wu and Frost 2006; Tajadura Ortega et al. 2018)
PAK6 (Tajadura Ortega et al. 2018)

The following RHOH interactors have only been reported in a high throughput screen by Bagci et al. 2020, and are therefore annotated as candidate RHOH effectors:
CAV1 (Bagci et al. 2020).
DBN1 (Bagci et al. 2020)
DBT (Bagci et al. 2020)
FAM91A1 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MTR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
NSFL1C (Bagci et al. 2020)
OSBPL11 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RALGAPA1 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TUBA1B (Bagci et al. 2020)
UACA (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VCP (Bagci et al. 2020)
WDR11 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
20184954	RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1 alpha Wang, H, Zeng, X, Fan, Z, Lim, B	Cell. Signal.	2010
29510700	An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration Tajadura-Ortega, V, Garg, R, Allen, R, Owczarek, C, Bright, MD, Kean, S, Mohd-Noor, A, Grigoriadis, A, Elston, TC, Hahn, KM, Ridley, AJ	BMC Biol.	2018
20851766	RhoH modulates pre-TCR and TCR signalling by regulating LCK Wang, H, Zeng, X, Fan, Z, Lim, B	Cell. Signal.	2011
17028588	RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development Gu, Y, Chae, HD, Siefring, JE, Jasti, AC, Hildeman, DA, Williams, DA	Nat. Immunol.	2006
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
17064668	Multiple Rho proteins regulate the subcellular targeting of PAK5 Wu, X, Frost, JA	Biochem. Biophys. Res. Commun.	2006