ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE

Stable Identifier
R-HSA-9018858
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Unlike resolvin E3, which is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway, resolvins E1 and E2 are biosynthesised by neutrophils via the 5-lipoxygenase pathway. In neutrophils, ALOX5 oxidises 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) to 5(S)-hydroperoxy-18(S)-hydroxyeicosapentaenoic acid (5(S)-Hp-18(S)-HEPE) (Tjonahen et al. 2006, Oh et al. 2012).
Literature References
PubMed ID Title Journal Year
17114001 Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis

Serhan, CN, Arita, M, Percarpio, KB, Oh, SF, Elangovan, S, Hong, S, Tjonahen, E, Siegelman, J

Chem. Biol. 2006
22450811 Resolvin E2 formation and impact in inflammation resolution

Serhan, CN, Dona, M, Krishnamoorthy, S, Irimia, D, Oh, SF, Fredman, G

J. Immunol. 2012
Participants
Participates
Catalyst Activity

arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]

Orthologous Events
Cross References
Rhea
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