ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA

Stable Identifier
R-HSA-9020259
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA
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Lipoxygenase 5 (ALOX5) can oxidise 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) into two hydroperoxy intermediates in human polymorphonuclear leukocytes (PMNs) (Serhan et al. 2002). The formation of 4(S)-hydroperoxy-17(R)-hydroxydocosahexaenoic acid (4(S)-Hp-17(R)-HDHA) is decribed here.

Literature References
PubMed ID Title Journal Year
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Serhan, CN, Hong, S, Gronert, K, Colgan, SP, Devchand, PR, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arachidonate 5-lipoxygenase activity of ALOX5 [cytosol]
Physical Entity
ALOX5 [cytosol]
Activity
arachidonate 5-lipoxygenase activity (0004051)
Orthologous Events
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Gallus gallus)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)
ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)
Authored
Jassal, B  (2017-09-05)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-09-05)
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