GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

Stable Identifier
R-HSA-9020271
Type
Reaction
Species
Homo sapiens
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Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(R)-hydroperoxy-docosahexaenoic acid (17(R)-Hp-DHA) to 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013). 17(R)-HDHA can then be transformed into 17(R)-D-resolvins and a 17-oxo electrophilic product 17-oxo-DHA (Groeger et al. 2010).

Literature References
PubMed ID Title Journal Year
8605014 Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury

Yagi, K, Komura, S, Kojima, H, Sun, Q, Nagata, N, Ohishi, N, Nishikimi, M

Biochem. Biophys. Res. Commun. 1996
24170573 Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase

Han, X, Fan, Z, Yu, Y, Liu, S, Hao, Y, Huo, R, Wei, J

IUBMB Life 2013
Participants
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Catalyst Activity
Title
phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
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Orthologous Events
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