GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA

Stable Identifier
R-HSA-9020271
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(R)-hydroperoxy-docosahexaenoic acid (17(R)-Hp-DHA) to 17(R)-hydroxydocosahexaenoic acid (17(R)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013). 17(R)-HDHA can then be transformed into 17(R)-D-resolvins and a 17-oxo electrophilic product 17-oxo-DHA (Groeger et al. 2010).
Literature References
PubMed ID Title Journal Year
24170573 Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase

Hao, Y, Fan, Z, Yu, Y, Huo, R, Han, X, Wei, J, Liu, S

IUBMB Life 2013
8605014 Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury

Nagata, N, Komura, S, Ohishi, N, Sun, Q, Yagi, K, Nishikimi, M, Kojima, H

Biochem. Biophys. Res. Commun. 1996
Participants
Participates
Catalyst Activity

phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]

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