ALOX15 oxidises DHA to 17(S)-Hp-DHA

Stable Identifier
R-HSA-9020275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the absence of aspirin in human whole blood, isolated leukocytes and glial cells, 15-lipoxygenase (ALOX15) can oxygenate docosahexanoic acid (DHA) (Kim et al. 1990) to the 17(S) epimer 17(S)-hydroperoxy-docosahexanoic acid (17(S)-Hp-DHA) (Hong et al. 2003). This intermediate leads to the production of 17(S) epimer D-resolvins (as opposed to aspirin-triggered 17(R) epimer D-resolvins), as well as being the precursor for protectins and the proposed precursor for the production of protectin conjugates in tissue regeneration (PCTRs) and resolvin conjugates in tissue regeneration (RCTRs) (Dalli et al. 2015, Ramon et al. 2016).

Literature References
PubMed ID Title Journal Year
12590139 Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation

Hong, S, Gronert, K, Devchand, PR, Moussignac, RL, Serhan, CN

J. Biol. Chem. 2003
2147774 Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets

Kim, HY, Karanian, JW, Salem, N

Prostaglandins 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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