GRIN2B gene expression is inhibited by MECP2

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R-HSA-9020513
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Reaction [omitted]
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Homo sapiens
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Based on the study in rats, transcription of the GRIN2B (NR2B) gene, encoding glutamate (NMDA) receptor subunit epsilon-2, is inhibited by promoter methylation and subsequent MECP2 binding. GRIN2B promoter methylation and MECP2 binding are stimulated by neuronal activity. Suppression of neuronal activity leads to demethylation of the GRIN2B promoter and increased GRIN2B transcription (Lee et al. 2008).

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