Reactome | TUBB [cytosol]

TUBB [cytosol]

Stable Identifier

R-HSA-9020816

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tubulin beta-5 chain, TUBB5

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07437 TUBB

Gene Names

TUBB, TUBB5, OK/SW-cl.56

Chain

chain:1-444

Reference Genes

BioGPS Gene:203068 TUBB

COSMIC (genes):TUBB TUBB

CTD Gene:203068 TUBB

dbSNP Gene:203068 TUBB

ENSEMBL:ENSG00000183311 TUBB

ENSEMBL:ENSG00000196230 TUBB

ENSEMBL:ENSG00000224156 TUBB

ENSEMBL:ENSG00000227739 TUBB

ENSEMBL:ENSG00000229684 TUBB

ENSEMBL:ENSG00000232421 TUBB

ENSEMBL:ENSG00000232575 TUBB

ENSEMBL:ENSG00000235067 TUBB

HGNC:20778 TUBB

KEGG Gene (Homo sapiens):203068 TUBB

Monarch:203068 TUBB

NCBI Gene:203068 TUBB

OMIM:191130 TUBB

Reference Transcript

Other Identifiers

0105720333

11724732_s_at

11748481_x_at

11752877_x_at

11752922_x_at

11753356_x_at

11753891_x_at

151_s_at

17006378

17026211

17027559

17030404

17033109

17035229

17037888

17040602

203068

209026_x_at

211714_x_at

212320_at

2336645

2901914

2901915

2901919

2901921

2901922

2901923

2901924

2901925

2901926

2901927

2901928

2901929

3003006

3092397

3092398

3092399

3092401

3092405

3511256

8117995

8177858

8179174

A_23_P387057

A_23_P81912

GE61339

GO:0000086

GO:0000166

GO:0000226

GO:0000278

GO:0002376

GO:0003674

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005641

GO:0005737

GO:0005764

GO:0005773

GO:0005856

GO:0005874

GO:0006810

GO:0006950

GO:0007010

GO:0007017

GO:0007049

GO:0008150

GO:0009987

GO:0010389

GO:0016192

GO:0019899

GO:0019904

GO:0022607

GO:0030705

GO:0031410

GO:0031625

GO:0032794

GO:0032991

GO:0035578

GO:0036464

GO:0042267

GO:0042288

GO:0043167

GO:0043226

GO:0043312

GO:0044297

GO:0044877

GO:0045121

GO:0051225

GO:0051301

GO:0070062

GO:0097711

Hs.179661.5.A1_3p_at

ILMN_1665583

ILMN_1704750

ILMN_2101885

J00314_at

PH_hs_0029875

TC06000347.hg

TC6_apd_hap1000029.hg

TC6_cox_hap2000045.hg

TC6_dbb_hap3000038.hg

TC6_mann_hap4000040.hg

TC6_mcf_hap5000032.hg

TC6_qbl_hap6000038.hg

TC6_ssto_hap7000038.hg

V00599_s_at

g4929137_3p_s_at

Participant Of

hasComponent

TUBB:colchicine [cytosol]

input

TUBB binds colchicine

Other forms of this molecule

TUBB [azurophil granule lumen]

TUBB [extracellular region]

Cross References

RefSeq

NP_001280142.1, NP_001280144.1, NP_821133.1, NP_001280145.1, NP_001280143.1, NP_001280141.1

Target Pathogen

5b354852be737e166372e78e, 5b2801b2be737e35a6debc5e, 57c0ab8fbe737e1cc0a9d73e, 5b354852be737e166372e74d, 57c0987cbe737e1cc0a98056, 5b2801b2be737e35a6deaee9, 5b2801b2be737e35a6de72c3, 57c0a8f7be737e1cc0a9ad2d, 57c0a8f7be737e1cc0a9ad2c, 5b2801b2be737e35a6de77f1, 5b2801b2be737e35a6de77f3, 5b2801b2be737e35a6de7cae, 5b2801b2be737e35a6dea49b

OpenTargets

ENSG00000196230

HPA

ENSG00000196230-TUBB

GeneCards

P07437

Ensembl

ENSP00000373058, ENSP00000339001, ENST00000327892, ENST00000383564, ENST00000422674, ENSP00000406811, ENST00000422650, ENSP00000401317, ENSP00000410829, ENST00000421473, ENSG00000196230, ENSG00000224156, ENSG00000229684, ENSP00000410071, ENST00000436628, ENSG00000232575, ENSG00000232421, ENST00000419792, ENSG00000183311, ENST00000432462, ENSG00000235067, ENSP00000399155, ENSG00000227739, ENSP00000400663

PRO

P07437

Orphanet

23571

HMDB Protein

HMDBP08048

PDB

3QNZ, 6QVE, 5N5N, 3QO0, 6QUY, 6QVJ, 6QUS, 6I2I

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.744	6
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.666	4
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	5
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P36957 DLST	2	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:Q03403 TFF2			0.556	3
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:Q13501 SQSTM1	2	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961)	0.556	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q8N448 LNX2			0.553	2
UniProt:Q05322 VP24			0.527	3
UniProt:Q77M19 Q77M19			0.527	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.508	2
UniProt:Q8AZK7 EBNA5			0.499	3
UniProt:Q00005 2ABB			0.462	2

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