Reactome | EZR [cytosol]

EZR [cytosol]

Stable Identifier

R-HSA-9020826

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cytovillin, p81

Locations in the PathwayBrowser for interactor UniProt:O14745

Expand all

External Reference Information

External Reference

UniProt:P15311 EZR

Gene Names

EZR, VIL2

Chain

chain:1-586

Reference Genes

BioGPS Gene:7430 EZR

COSMIC (genes):EZR EZR

CTD Gene:7430 EZR

dbSNP Gene:7430 EZR

ENSEMBL:ENSG00000092820 EZR

HGNC:12691 EZR

KEGG Gene (Homo sapiens):7430 EZR

Monarch:7430 EZR

NCBI Gene:7430 EZR

OMIM:123900 EZR

UCSC:P15311 EZR

Reference Transcript

Other Identifiers

0002360132

11742987_s_at

11742988_s_at

11742989_a_at

11742990_x_at

11749746_s_at

17025189

17025191

208621_s_at

208622_s_at

208623_s_at

217234_s_at

2634427

2981913

2981914

2981915

2981916

2981917

2981918

2981919

2981920

2981923

2981924

2981926

2981927

2981928

2981930

2981931

2981932

2981935

2981940

2981942

2981943

2981948

2981949

2981953

2981967

2981968

2981969

40103_at

7430

8130505

A_23_P19590

A_24_P290481

GE81271

GO:0000122

GO:0000902

GO:0001650

GO:0001726

GO:0001772

GO:0001931

GO:0001951

GO:0002376

GO:0003376

GO:0003674

GO:0003723

GO:0003779

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005730

GO:0005737

GO:0005768

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005902

GO:0005903

GO:0005925

GO:0005929

GO:0005938

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007159

GO:0007165

GO:0007411

GO:0008017

GO:0008022

GO:0008092

GO:0008150

GO:0008360

GO:0009056

GO:0009058

GO:0010628

GO:0010737

GO:0015031

GO:0015629

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0019898

GO:0019899

GO:0019904

GO:0022607

GO:0022614

GO:0030033

GO:0030154

GO:0030175

GO:0030315

GO:0030855

GO:0030863

GO:0030953

GO:0031410

GO:0031528

GO:0031532

GO:0031623

GO:0031982

GO:0032532

GO:0032587

GO:0032703

GO:0032991

GO:0034236

GO:0034237

GO:0034629

GO:0034641

GO:0035088

GO:0036064

GO:0040007

GO:0040011

GO:0040018

GO:0042802

GO:0042995

GO:0043226

GO:0043622

GO:0044297

GO:0044393

GO:0044548

GO:0044853

GO:0044877

GO:0045121

GO:0045177

GO:0045296

GO:0046847

GO:0048015

GO:0048471

GO:0048856

GO:0050714

GO:0050839

GO:0050860

GO:0051015

GO:0051017

GO:0051018

GO:0051117

GO:0051286

GO:0051660

GO:0061028

GO:0070062

GO:0070373

GO:0071320

GO:0071944

GO:0072659

GO:0072697

GO:0097449

GO:0097454

GO:0097718

GO:0098592

GO:1902115

GO:1902896

GO:1902966

GO:1903078

GO:1903364

GO:1903753

GO:2000643

HMNXSV003005896

HMNXSV003008544

HMNXSV003047824

Hs.155191.0.S1_3p_a_at

Hs.155191.0.S2_3p_a_at

Hs.155191.1.S1_3p_a_at

ILMN_1795937

ILMN_3272378

PH_hs_0024623

TC06002264.hg

TC06002265.hg

X51521_at

g340216_3p_a_at

Participates

as an input of

Translocation of Ezrin to plasma membrane (Homo sapiens)

as a component of

EZR:PIP2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y146,Y354-EZR [cytosol]

p-T567-EZR [cytosol]

Inferred To

EZR [cytosol] (Canis familiaris)

EZR [cytosol] (Gallus gallus)

EZR [cytosol] (Sus scrofa)

erm-1 [cytosol] (Caenorhabditis elegans)

Moe [cytosol] (Drosophila melanogaster)

Ezr [cytosol] (Mus musculus)

Ezr [cytosol] (Rattus norvegicus)

ezrb [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001104547.1, NP_003370.2

Target Pathogen

5b354852be737e166372e87b

OpenTargets

ENSG00000092820

ZINC - Substances

EZRI_HUMAN

GeneCards

P15311

HPA

ENSG00000092820-EZR

ZINC target

P15311

Ensembl

ENSP00000356042, ENST00000337147, ENSG00000092820, ENSP00000338934, ENST00000367075

PRO

P15311

Orphanet

23599

PDB

1NI2, 4RMA, 4RM9, 4RM8

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.852	7
UniProt:P15311 EZR	3	p-T567-EZR [cytosol] (R-HSA-374559) p-Y146,Y354-EZR [cytosol] (R-HSA-374572) EZR [cytosol] (R-HSA-9020826)	0.783	8
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.689	6
UniProt:P07332 FES	1	FES [cytosol] (R-HSA-396937)	0.678	8
UniProt:Q8IVT2 MISP			0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P26447 S10A4			0.611	3
UniProt:P23508 CRCM			0.589	2
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.589	3
UniProt:P26038 MSN	2	MSN [cytosol] (R-HSA-437350) p-T558-MSN [cytosol] (R-HSA-9663005)	0.569	5
UniProt:Q8WU43 CB015			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:Q8N108-16 MIER1			0.556	3
UniProt:Q14457 BECN1	3	BECN1 [cytosol] (R-HSA-1632841) K63polyUb-BECN1 [cytosol] (R-HSA-6782989) p-S15-BECN1 [cytosol] (R-HSA-5682391)	0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:P29034 S10A2			0.544	2
UniProt:Q00987 MDM2	11	SUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:Q63155 Dcc	5	phospho-Dcc [plasma membrane] (R-RNO-374552) DCC [plasma membrane] (R-RNO-421662) Dcc [cytosol] (R-RNO-373629) Dcc [plasma membrane] (R-RNO-197560) Dcc [plasma membrane] (R-RNO-373627)	0.524	3
UniProt:Q9BXI6 TBC1D10A	2	TBC1D10A [microvillus] (R-HSA-8854143) TBC1D10A [cytosol] (R-HSA-8854139)	0.491	2
UniProt:Q8IZE3 PACE1			0.463	4
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.463	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

Cite Us!