MECP2 mRNA translation is inhibited by miR-132

Stable Identifier
R-HSA-9021183
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MECP2 mRNA translation is inhibited by miR-132
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice and rats, miR-132 reduces both mRNA and protein levels of MECP2. miR-132 is therefore expected to function in the context of the endonucleolytic RISC, and possibly also non-endonucleolytic RISC. MicroRNA miR-132 is complementary to the 3'UTR of long MECP2 transcripts (>10 kb), which are predominantly expressed in the brain (Klein et al. 2007, Su et al. 2015). Based on sequence similarity, human MECP2 mRNA is also predicted to be a miR-132 target.
Literature References
PubMed ID Title Journal Year
17994015 Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Klein, ME, Lioy, DT, Ma, L, Impey, S, Mandel, G, Goodman, RH

Nat. Neurosci. 2007
26239616 MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression

Su, M, Hong, J, Zhao, Y, Liu, S, Xue, X

Mol Med Rep 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2 mRNA:miR-132 RISC [cytosol] (Homo sapiens)
Active Unit
miR-132 RISC [cytosol]
Inferred From
Mecp2 mRNA translation is inhibited by miR-132 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-15)
Cite Us!