WWP2, an E3 ubiquitin ligase, can interact with NOTCH3 cleavage products NEXT3 and NICD3 in the cytosol. The interaction involves the PPPY motif in the PEST domain of NOTCH3 (Jung et al. 2014).
Jung, JG, Stoeck, A, Guan, B, Wu, RC, Zhu, H, Blackshaw, S, Shih, IeM, Wang, TL
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