NOTCH3 binds WWP2

Stable Identifier
R-HSA-9021520
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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WWP2, an E3 ubiquitin ligase, can interact with NOTCH3 cleavage products NEXT3 and NICD3 in the cytosol. The interaction involves the PPPY motif in the PEST domain of NOTCH3 (Jung et al. 2014).

Literature References
PubMed ID Title Journal Year
25356737 Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Jung, JG, Stoeck, A, Guan, B, Wu, RC, Zhu, H, Blackshaw, S, Shih, IeM, Wang, TL

PLoS Genet. 2014
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Participant Of
Event Information
Orthologous Events
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