NOTCH3 binds WWP2

Stable Identifier
R-HSA-9021520
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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NOTCH3 binds WWP2
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WWP2, an E3 ubiquitin ligase, can interact with NOTCH3 cleavage products NEXT3 and NICD3 in the cytosol. The interaction involves the PPPY motif in the PEST domain of NOTCH3 (Jung et al. 2014).

Literature References
PubMed ID Title Journal Year
25356737 Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Jung, JG, Stoeck, A, Guan, B, Wu, RC, Zhu, H, Blackshaw, S, Shih, IeM, Wang, TL

PLoS Genet. 2014
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Orthologous Events
NOTCH3 binds WWP2 (Bos taurus)
NOTCH3 binds WWP2 (Mus musculus)
NOTCH3 binds WWP2 (Rattus norvegicus)
NOTCH3 binds WWP2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-19)