WWP2 ubiquitinates NOTCH3

Stable Identifier
R-HSA-9021523
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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WWP2 ubiquitinates NOTCH3
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WWP2, an E3 ubiquitin ligase, ubiquitinates NOTCH3 cleavage fragments NEXT3 and NICD3 in the cytosol, targeting them for lysosome-mediated degradation. WWP2 thus negatively regulates NOTCH3 signaling. WWP2 is a putative tumor suppressor whose deletions have been reported in the majority of ovarian carcinomas (Jung et al. 2014).
Literature References
PubMed ID Title Journal Year
25356737 Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Wu, RC, Guan, B, Blackshaw, S, Wang, TL, Zhu, H, Stoeck, A, Shih, IeM, Jung, JG

PLoS Genet. 2014
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Catalyst Activity

ubiquitin protein ligase activity of NEXT3,NICD3:WWP2 [cytosol]

Physical Entity
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
WWP2 ubiquitinates NOTCH3 (Gallus gallus)
WWP2 ubiquitinates NOTCH3 (Mus musculus)
WWP2 ubiquitinates NOTCH3 (Rattus norvegicus)
WWP2 ubiquitinates NOTCH3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-19)
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