WWP2 ubiquitinates NOTCH3

Stable Identifier
R-HSA-9021523
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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WWP2, an E3 ubiquitin ligase, ubiquitinates NOTCH3 cleavage fragments NEXT3 and NICD3 in the cytosol, targeting them for lysosome-mediated degradation. WWP2 thus negatively regulates NOTCH3 signaling. WWP2 is a putative tumor suppressor whose deletions have been reported in the majority of ovarian carcinomas (Jung et al. 2014).

Literature References
PubMed ID Title Journal Year
25356737 Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Jung, JG, Stoeck, A, Guan, B, Wu, RC, Zhu, H, Blackshaw, S, Shih, IeM, Wang, TL

PLoS Genet. 2014
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of NEXT3,NICD3:WWP2 [cytosol]
Physical Entity
Activity
Orthologous Events
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