Reactome | Membrane estrogen receptors bind SRC

Membrane estrogen receptors bind SRC

Stable Identifier

R-HSA-9021596

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Rapid signaling downstream of estrogen stimulation activates signaling through MAP kinase and PI3K/AKT signaling pathways, as well as initiating cross-talk with NF kappa beta and receptor tyrosine kinase pathways (reviewed in Hammes et al, 2007; Handa et al, 2012; Lange et al, 2017; Losel et al, 2003). Signaling through AKT regulates cell cycle progression through CREB-mediated upregulation of cyclin D1 and depends on recruitment of SRC and the p85 regulatory subunit of PI3K (Castoria et al, 2001; Marino et al, 2002; Marino et al, 2003; Castoria et al, 2012; reviewed in Castoria et al, 2010). Estrogen-stimulated nitric oxide (NO) release from endothelial cells likewise depends on the recruitment of SRC to the estrogen receptors at the plasma membrane (Haynes et al, 2003).
Once recruited, SRC is activated by autophosphorylation at tyrosine 419, which in turn is required for the recruitment and activation of PI3K and AKT, and ultimately for the activation of endothelial nitric oxide synthase (eNOS) and promotion of AKT-dependent cellular proliferation (Haynes et al, 2000; Simoncini et al, 2000; Haynes et al, 2003; Li et al, 2007; reviewed in Kim and Bender, 2005; Hammes and Levin, 2011; Le Romancer et al, 2011: Castoria et al, 2010). Formation of an eNOS signaling complex also depends on interaction between the estrogen receptor and heterotrimeric G-proteins (Wyckoff et al, 2001; reviewed in Schwartz, 2016).

Literature References

PubMed ID	Title	Journal	Year
17921256	Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation Li, L, Hisamoto, K, Kim, KH, Haynes, MP, Bauer, PM, Sanjay, A, Collinge, M, Baron, R, Sessa, WC, Bender, JR	Proc. Natl. Acad. Sci. U.S.A.	2007
21851428	Roles for oestrogen receptor β in adult brain function Handa, RJ, Ogawa, S, Wang, JM, Herbison, AE	J. Neuroendocrinol.	2012
12511868	Nongenomic actions of steroid hormones Lösel, R, Wehling, M	Nat. Rev. Mol. Cell Biol.	2003
19879889	Cell proliferation regulated by estradiol receptor: Therapeutic implications Castoria, G, Migliaccio, A, Giovannelli, P, Auricchio, F	Steroids	2010
15956360	Rapid, estrogen receptor-mediated signaling: why is the endothelium so special? Kim, KH, Bender, JR	Sci. STKE	2005
22028449	Minireview: Recent advances in extranuclear steroid receptor actions Hammes, SR, Levin, ER	Endocrinology	2011
12431978	Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen Haynes, MP, Li, L, Sinha, D, Russell, KS, Hisamoto, K, Baron, R, Collinge, M, Sessa, WC, Bender, JR	J. Biol. Chem.	2003
11029403	Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells Haynes, MP, Sinha, D, Russell, KS, Collinge, M, Fulton, D, Morales-Ruiz, M, Sessa, WC, Bender, JR	Circ. Res.	2000
17037979	Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer Lange, CA, Gioeli, D, Hammes, SR, Marker, PC	Annu. Rev. Physiol.	2007
17916740	Extranuclear steroid receptors: nature and actions Hammes, SR, Levin, ER	Endocr. Rev.	2007
11369763	Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i) Wyckoff, MH, Chambliss, KL, Mineo, C, Yuhanna, IS, Mendelsohn, ME, Mumby, SM, Shaul, PW	J. Biol. Chem.	2001
12808053	Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells Marino, M, Acconcia, F, Trentalance, A	Mol. Biol. Cell	2003
22266855	Tyrosine phosphorylation of estradiol receptor by Src regulates its hormone-dependent nuclear export and cell cycle progression in breast cancer cells Castoria, G, Giovannelli, P, Lombardi, M, De Rosa, C, Giraldi, T, de Falco, A, Barone, MV, Abbondanza, C, Migliaccio, A, Auricchio, F	Oncogene	2012
12388769	Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells Marino, M, Acconcia, F, Bresciani, F, Weisz, A, Trentalance, A	Mol. Biol. Cell	2002
11029009	Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase Simoncini, T, Hafezi-Moghadam, A, Brazil, DP, Ley, K, Chin, WW, Liao, JK	Nature	2000
27288742	Rapid steroid hormone actions via membrane receptors Schwartz, N, Verma, A, Bivens, CB, Schwartz, Z, Boyan, BD	Biochim. Biophys. Acta	2016
21680538	Cracking the estrogen receptor's posttranslational code in breast tumors Le Romancer, M, Poulard, C, Cohen, P, Sentis, S, Renoir, JM, Corbo, L	Endocr. Rev.	2011
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F	EMBO J.	2001