PTPN1 gene expression is inhibited by MECP2

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R-HSA-9023549
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Reaction [omitted]
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Homo sapiens
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MECP2 directly represses PTPN1 (PTP1B) gene transcription in both human and mouse cells (Krishnan et al. 2015). PTPN1 can dephosphorylated BDNF receptor TRKB, which negatively regulates BDNF signaling. Increased PTPN1 level, which is a consequence of the loss of function of MECP2, interferes with BDNF signaling (Krishnan et al. 2015).

Literature References
PubMed ID Title Journal Year
26214522 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

Krishnan, N, Krishnan, K, Connors, CR, Choy, MS, Page, R, Peti, W, Van Aelst, L, Shea, SD, Tonks, NK

J. Clin. Invest. 2015
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