DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)

Stable Identifier
R-HSA-9023627
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GIP, inactivating it. DPP4 determines the half life of GIP in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GIP.
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of DPP4(1-766) [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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