Reactome | DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

Stable Identifier

R-HSA-9023632

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)

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Dipeptidyl Peptidase IV (DPP4) cleaves 2 amino acids from the N-terminus of GLP-1, inactivating it. DPP4 determines the half life of GLP-1 in the bloodstream. It is unknown if the soluble form of DPP4, the membrane-bound form, or both catalyze the cleavage of GLP-1.

Literature References

PubMed ID	Title	Journal	Year
14719797	Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme Demuth, HU, Stork, J, Bar, J, Weber, A, Hoffmann, T, Gerhartz, B, Wagner, L, Aust, S, Wermann, M	Biol Chem	2003
7883856	Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo Johnsen, AH, Holst, JJ, Deacon, CF	J Clin Endocrinol Metab	1995
15584901	Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders Gorrell, MD	Clin Sci (Lond)	2005
8798518	Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach Pauly, RP, Demuth, HU, Rosche, F, McIntosh, CH, Pederson, RA, Wermann, M	J Biol Chem	1996
8100523	Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum Schmidt, WE, Mentlein, R, Gallwitz, B	Eur J Biochem	1993