ESR1:ESTG binds to proximal and distal regions of the CTSD promoter

Stable Identifier
R-HSA-9023845
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cathepsin D (CTSD) is an estrogen-responsive gene encoding a lysosomal protease with roles in cellular proliferation, apoptosis, cell migration and differentiation, among others (reviewed in Zaidi et al, 2008; Khalkhali-Ellis and Hendrix, 2015). Estrogen-dependence is conferred by the presence of non-canonical EREs in the proximal and distal promoter regions which are bound by ESR1 in a ligand-dependent manner (Augereau et al, 1994; Cavaillès et al, 1993; Wang et al, 1997; Wang et al, 1998; Xing and Archer, 1998; Shang et al, 2000; Wang et al, 2001; Bourdeau et al, 2004). Estrogen-stimulated transcriptional activation is facilitated by the formation of ESR1-dependent loops and by the cyclic recruitment of activators, coactivators, HATs and other components of the general transcriptional machinery (Shang et al, 2000; Bretschneider et al, 2008).

Literature References
PubMed ID Title Journal Year
9611253 Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes

Wang, F, Hoivik, D, Pollenz, R, Safe, S

Nucleic Acids Res. 1998
9731700 Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter

Xing, W, Archer, TK

Mol. Endocrinol. 1998
11136970 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

Shang, Y, Hu, X, DiRenzo, J, Lazar, MA, Brown, M

Cell 2000
25663755 Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon

Khalkhali-Ellis, Z, Hendrix, MJ

Biol Med (Aligarh) 2014
18762174 Cathepsin D: a cellular roadmap

Zaidi, N, Maurer, A, Nieke, S, Kalbacher, H

Biochem. Biophys. Res. Commun. 2008
7935485 Characterization of the proximal estrogen-responsive element of human cathepsin D gene

Augereau, P, Miralles, F, Cavaillès, V, Gaudelet, C, Parker, M, Rochefort, H

Mol. Endocrinol. 1994
15001666 Genome-wide identification of high-affinity estrogen response elements in human and mouse

Bourdeau, V, Deschênes, J, Métivier, R, Nagai, Y, Nguyen, D, Bretschneider, N, Gannon, F, White, JH, Mader, S

Mol. Endocrinol. 2004
19383337 E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements

Bretschneider, N, Kangaspeska, S, Seifert, M, Reid, G, Gannon, F, Denger, S

Mol Oncol 2008
9201922 Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene

Wang, F, Porter, W, Xing, W, Archer, TK, Safe, S

Biochemistry 1997
8419924 Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells

Cavaillès, V, Augereau, P, Rochefort, H

Proc. Natl. Acad. Sci. U.S.A. 1993
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