Histone acetyltransferases are recruited to the TFF1 gene

Stable Identifier
R-HSA-9023860
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Estrogen-dependent expression of TFF1 depends on the recruitment of histone acetyltransferases such as KAT5, EP300, CITED1 and KAT2B, as well as coactivators such as NCOA1 and NCOA3 (Métivier et al, 2003; reviewed in Arnal et al, 2017). ChIP analysis suggests that NCOA1 and NCOA3 do not co-occupy the TFF1 promoter, but may be differentially recruited under different conditions (Métivier et al, 2003). Note that the acetyltransferase activity of these HATs is not depicted in this diagram.

Literature References
PubMed ID Title Journal Year
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F

Cell 2003
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J

Physiol. Rev. 2017
Participants
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Orthologous Events
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