Reactome | Histone acetyltransferases are recruited to the TFF1 gene

Histone acetyltransferases are recruited to the TFF1 gene

Stable Identifier

R-HSA-9023860

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Histone acetyltransferases are recruited to the TFF1 gene

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Estrogen-dependent expression of TFF1 depends on the recruitment of histone acetyltransferases such as KAT5, EP300, CITED1 and KAT2B, as well as coactivators such as NCOA1 and NCOA3 (Métivier et al, 2003; reviewed in Arnal et al, 2017). ChIP analysis suggests that NCOA1 and NCOA3 do not co-occupy the TFF1 promoter, but may be differentially recruited under different conditions (Métivier et al, 2003). Note that the acetyltransferase activity of these HATs is not depicted in this diagram.

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M	Physiol. Rev.	2017
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR	Cell	2003