PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene

Stable Identifier
R-HSA-9023861
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PRMT1 is an H4 R3 methyltransferase that is recruited to the TFF promoter where, in conjunction with acetyltransferases, it establishes transcriptionally active chromatin (Métivier et al, 2003. CARM1 is an alternate arginine methyltransferase with activity toward H3 R17 that acts at the TFF enhancer, however CARM1 and PRMT1 are never found simultaneously at the TFF1 gene (Métivier et al, 2003; reviewed in Xu et al, 2003; Arnal et al, 2017).Note that in this diagram, methylation of H4 R3 is not depicted.

Literature References
PubMed ID Title Journal Year
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F

Cell 2003
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J

Physiol. Rev. 2017
14631847 Acetylation and methylation in nuclear receptor gene activation

Xu, W, Cho, H, Evans, RM

Meth. Enzymol. 2003
Participants
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Orthologous Events
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