ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA

Stable Identifier
R-HSA-9024983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In macrophages, lipoxygenase 12 (ALOX12:Fe2+) may abstract hydrogen from 14(S)-hydroperoxy-docosaheaenoic acid (14(S)-Hp-DHA) to form 13(S),14(S)-epoxy-DHA (Serhan et al. 2009, Dalli et al. 2013, Deng et al. 2014). This epoxy product is a central intermediate in maresin MaR1 and MaR2 and maresin conjugates in tissue regeneration (MCTR) biosyntheses (Dalli et al. 2016) as well as possessing potent proresolving activity (Dalli et al 2013).

Literature References
PubMed ID Title Journal Year
23504711 The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

Dalli, J, Zhu, M, Vlasenko, NA, Deng, B, Haeggström, JZ, Petasis, NA, Serhan, CN

FASEB J. 2013
25036362 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages

Deng, B, Wang, CW, Arnardottir, HH, Li, Y, Cheng, CY, Dalli, J, Serhan, CN

PLoS ONE 2014
19103881 Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

Serhan, CN, Yang, R, Martinod, K, Kasuga, K, Pillai, PS, Porter, TF, Oh, SF, Spite, M

J. Exp. Med. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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