EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2

Stable Identifier
R-HSA-9024993
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dimeric bifunctional epoxide hydrolase 2 (EPHX2 dimer, soluble epoxide hydrolase, sEH) hydrolyses 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form 13(R),14(S)-dihydroxy-docosahexaenoic acid, aka maresin 2 (MaR2) (Deng et al. 2014). Like MaR1, MaR2 possesses anti-inflammatory and pro-resolving activities although it is not as potent as MaR1 (Deng et al. 2014).

Literature References
PubMed ID Title Journal Year
25036362 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages

Deng, B, Wang, CW, Arnardottir, HH, Li, Y, Cheng, CY, Dalli, J, Serhan, CN

PLoS ONE 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
epoxide hydrolase activity of EPHX2 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!