Biosynthesis of DPAn-6 SPMs

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R-HSA-9025106
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Homo sapiens
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The biosynthesis of specialised proresolving mediators (SPMs) derived from the ω-6 isomer of DPA, DPAn-6 (cis-4,7,10,13,16-docosapentaenoic acid) is described here (Dangi et al. 2010). The products of the ω-6 isomer were characterised by analogy in structure and action to docosahexaenoic acid (DHA)-derived and eicosapentaenoic acid (EPA)-derived resolvins (Serhan et al. 2002, Bannenberg & Serhan 2010).

Literature References
PubMed ID Title Journal Year
19679107 Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6)

Dangi, B, Obeng, M, Nauroth, JM, Chung, G, Bailey-Hall, E, Hallenbeck, T, Arterburn, LM

Biochem. Pharmacol. 2010
26546723 Docosapentaenoic acid derived metabolites and mediators - The new world of lipid mediator medicine in a nutshell

Weylandt, KH

Eur. J. Pharmacol. 2016
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