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NTF4 binds NTRK2
Stable Identifier
R-HSA-9026358
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
NTF4 activates NTRK2 (TRKB) signaling (Homo sapiens)
NTF4 binds NTRK2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The neurotrophic factor NTF4 (neurotrophin-4), which functions as a homodimer (Robinson et al. 1999), is a ligand for the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) (Klein et al. 1992, Ip et al. 1993, Ohira et al. 2001).
Participants
Input
NTF4 homodimer [extracellular region]
(Homo sapiens)
NTRK2 [plasma membrane]
(Homo sapiens)
Output
NTF4:NTRK2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
NTF4 activates NTRK2 (TRKB) signaling (Homo sapiens)
Inferred From
ntf4 binds Ntrk2 (Xenopus laevis)
Authored
Orlic-Milacic, M (2018-01-05)
Reviewed
Castrén, E (2018-02-13)
Antila, H (2018-02-13)
Created
Orlic-Milacic, M (2017-10-19)
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