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NTF4-bound NTRK2 dimerizes
Stable Identifier
R-HSA-9026377
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
NTF4 activates NTRK2 (TRKB) signaling (Homo sapiens)
NTF4-bound NTRK2 dimerizes (Homo sapiens)
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Based on studies in macaque monkeys, NTF4 (neurotrophin-4) binding induces dimerization of the NTRK2 (TRKB) receptor (Ohira et al. 2001).
Participants
Input
NTF4:NTRK2 [plasma membrane]
(Homo sapiens)
NTRK2 [plasma membrane]
(Homo sapiens)
Output
NTF4:NTRK2 homodimer [plasma membrane]
(Homo sapiens)
Participates
as an event of
NTF4 activates NTRK2 (TRKB) signaling (Homo sapiens)
Inferred From
NTF4-bound Ntrk2 dimerizes (Macaca mulatta)
Authored
Orlic-Milacic, M (2018-01-05)
Reviewed
Castrén, E (2018-02-13)
Antila, H (2018-02-13)
Created
Orlic-Milacic, M (2017-10-19)
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