Reactome | ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4

ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4

Stable Identifier

R-HSA-9026405

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
    - Biosynthesis of DPA-derived SPMs (Homo sapiens)
      - Biosynthesis of DPAn-3 SPMs (Homo sapiens)
        
        Biosynthesis of DPAn-3-derived 13-series resolvins (Homo sapiens)
        
        ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)

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In neutrophils, 5-lipoxygenase (ALOX5) oxidises 13(R)-hydroxy-docosapentaenoic acid (13(R)-DPAn-3) to the 13(R)-resolvins RvT1-4 (7,13,20-trihydroxy-docosapentaenoic acid, 7,12,13-trihydroxy-docosapentaenoic acid, 7,8,13-trihydroxy-docosapentaenoic acid and 7,13-dihydroxy-docosapentaenoic acid respectively) (Dalli et al. 2015, Primdahl et al. 2016). They were all shown to posses anti-inflammatory and proresolving activities (Dalli et al. 2015). Recently, RvTs have been shown to mediate the proresolving actions of several statins in mice with inflammatory arthritis (Walker et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
26236990	Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections Serhan, CN, Chiang, N, Dalli, J	Nat. Med.	2015
27704804	Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins Serhan, CN, Colas, RA, Primdahl, KG, Hansen, TV, Aursnes, M, Walker, ME, Vik, A, Dalli, J	J. Nat. Prod.	2016