PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

Stable Identifier
R-HSA-9026408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Incubation of ω-3 docosapentaenoic acid (DPAn-3) with human recombinant cyclooxygenase 2 (PTGS2 dimer, COX2) in vascular endothelial cells produces 13(R)-hydroxy-docasapentaenoic acid (13(R)-HDPAn-3), the precursor of 13(R)-resolvins and the electrophilic 13-oxo-DPAn-3 (Dalli et al. 2015, Primdahl et al. 2016).

Literature References
PubMed ID Title Journal Year
27704804 Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

Primdahl, KG, Aursnes, M, Walker, ME, Colas, RA, Serhan, CN, Dalli, J, Hansen, TV, Vik, A

J. Nat. Prod. 2016
26236990 Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

Dalli, J, Chiang, N, Serhan, CN

Nat. Med. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of PTGS2 dimer [endoplasmic reticulum membrane]
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Activity
Orthologous Events
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