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NTF4:p-5Y-NTRK2 [plasma membrane]
Stable Identifier
R-HSA-9026509
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NT-4:p-5Y-TRKB
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
Activated NTRK2 binds FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Activated NTRK2 binds FRS3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 activates RAS signaling through FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 phosphorylates FRS2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 phosphorylates FRS3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2-phosphorylated FRS2 binds GRB2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:PTPN11 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Activated NTRK2 signals through PI3K (Homo sapiens)
Activated NTRK2 recruits PI3K (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2-activated PI3K generates PIP3 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Activated NTRK2 signals through PLCG1 (Homo sapiens)
Activated PCLG1 dissociates from NTRK2 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 phosphorylates PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:PLCG1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Activated NTRK2 signals through RAS (Homo sapiens)
NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 phosphorylates SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
p-Y516 of p-5Y-NTRK2 recruits SHC1 (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:SHC1-2,SHC1-3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
NTF4 activates NTRK2 (TRKB) signaling (Homo sapiens)
NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
NTF4:p-5Y-NTRK2 [plasma membrane] (Homo sapiens)
Participants
components
NTF4 homodimer [extracellular region]
(Homo sapiens)
p-5Y-NTRK2 [plasma membrane]
(Homo sapiens)
Participates
as a component of
NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Homo sapiens)
Inferred To
NTF4:p-5Y-NTRK2 [plasma membrane]
(Bos taurus)
NTF4:p-5Y-NTRK2 [plasma membrane]
(Canis familiaris)
NTF4:p-5Y-NTRK2 [plasma membrane]
(Mus musculus)
NTF4:p-5Y-NTRK2 [plasma membrane]
(Rattus norvegicus)
NTF4:p-5Y-NTRK2 [plasma membrane]
(Sus scrofa)
NTF4:p-5Y-NTRK2 [plasma membrane]
(Xenopus tropicalis)
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