Activated NTRK2 signals through RAS

Stable Identifier
R-HSA-9026519
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Pathway
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Homo sapiens
ReviewStatus
5/5
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Activated NTRK2 signals through RAS
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Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).
Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L

Neuron 1998
10533983 The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL

Feinstein, SC, McCarty, JH

J. Recept. Signal Transduct. Res. 1999
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
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positive regulation of Ras protein signal transduction (0046579)
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BioModels Database
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-19)
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