NTRK2 activates RAS signaling through SHC1

Stable Identifier
R-HSA-9026891
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NTRK2 activates RAS signaling through SHC1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SHC1-mediated recruitment of GRB2:SOS1 to the activated NTRK2 (TRKB) receptor leads to activation of RAS signaling and downstream phosphorylation of ERK1 (MAPK3) and ERK2 (MAPK1) (Chan et al. 2001). SOS1 functions as a guanine-nucleotide exchange factor for RAS proteins, catalyzing exchange of GDP for GTP, resulting in formation of the active RAS:GTP complex (Chardin et al. 1993).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane]

Physical Entity
BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Inferred From
Ntrk2 activates Ras signaling through Shc1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-10-24)
Cite Us!