LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1

Stable Identifier
R-HSA-9026911
Type
Reaction
Species
Homo sapiens
Compartment
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Just as the addition of glutathione (GSH) to an allylic epoxide is governed by glutathione S-transferase enzymes in the biosynthesis of MCTR (Dalli et al. 2016), 7S(8)-epoxy-17(S)-hydroxy-docosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) may presumably be conjugated with GSH by trimeric leukotriene C4 synthase (LTC4S trimer) to form resolvin conjugate in tissue regeneration 1 (RCTR1, 8-glutathionyl, 7,17-dihydroxy-docosahexaenoic acid) (Dalli et al. 2015).

Literature References
PubMed ID Title Journal Year
25713027 Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

Dalli, J, Ramon, S, Norris, PC, Colas, RA, Serhan, CN

FASEB J. 2015
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Catalyst Activity
Title
glutathione transferase activity of LTC4S trimer [endoplasmic reticulum membrane]
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Orthologous Events
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