Reactome | Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Stable Identifier

R-HSA-9027276

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

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PI3K can bind the activated EPO receptor (EPOR) by three different mechanisms: direct binding to phospho-Y479 of the EPOR, indirect binding via phosphorylated IRS2 bound to the EPOR, and indirect binding via phosphorylated GAB1 bound to the EPOR (Bouscary et al. 2003, Schmidt et al. 2004, reviewed in Kuhrt and Wojchowski 2015). PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidylinositol 3,4,5-trisphosphate which recruits AKT1 to the membrane.

Literature References

PubMed ID	Title	Journal	Year
25887776	Emerging EPO and EPO receptor regulators and signal transducers Wojchowski, DM, Kuhrt, D	Blood	2015
12506011	Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation Claessens, YE, Mayeux, P, Fontenay-Roupie, M, Bouscary, D, Pene, F, Lacombe, C, Muller, O, Chrétien, S, Gisselbrecht, S	Blood	2003
15149544	PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors Schmidt, EK, Feller, SM, Fichelson, S	BMC Biol.	2004