Erythropoietin activates Phosphoinositide-3-kinase (PI3K)

Stable Identifier
R-HSA-9027276
Type
Pathway
Species
Homo sapiens
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PI3K can bind the activated EPO receptor (EPOR) by three different mechanisms: direct binding to phospho-Y479 of the EPOR, indirect binding via phosphorylated IRS2 bound to the EPOR, and indirect binding via phosphorylated GAB1 bound to the EPOR (Bouscary et al. 2003, Schmidt et al. 2004, reviewed in Kuhrt and Wojchowski 2015). PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate to yield phosphatidylinositol 3,4,5-trisphosphate which recruits AKT1 to the membrane.

Literature References
PubMed ID Title Journal Year
12506011 Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation

Bouscary, D, Pene, F, Claessens, YE, Muller, O, Chr├ętien, S, Fontenay-Roupie, M, Gisselbrecht, S, Mayeux, P, Lacombe, C

Blood 2003
25887776 Emerging EPO and EPO receptor regulators and signal transducers

Kuhrt, D, Wojchowski, DM

Blood 2015
15149544 PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors

Schmidt, EK, Fichelson, S, Feller, SM

BMC Biol. 2004
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Event Information
Orthologous Events
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BioModels Database
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