Erythropoietin activates Phospholipase C gamma (PLCG)

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R-HSA-9027277
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Pathway
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Homo sapiens
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PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activated EPOR is phosphorylated on tyrosine residues by the kinase LYN (Ren et al. 1994, and inferred from mouse homologs). PLCG1 and PLCG2 produce inositol 1,4,5-trisphosphate which then activates calcium signaling, and diacylglycerol (DAG) which then activates protein kinase C (PKC).

Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Komatsu, N, Shimizu, R, Okada, K, Miura, Y

J. Biol. Chem. 1994
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