Reactome | Erythropoietin activates RAS

Erythropoietin activates RAS

Stable Identifier

R-HSA-9027284

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The RAS guanine nucleotide exchange factors SOS1 and VAV1 bind indirectly to the phosphorylated EPOR via CRKL, SHC1, and GRB2 (Miura et al. 1994, Hanazono et al. 1996, Odai et al. 1997, Arai et al. 2001, reviewed in Kuhrt et al. 2015) . The phosphorylated cytoplasmic domain of EPOR binds CRKL, which is then phosphorylated (Arai et al. 2001). Phosphorylated CRKL binds SHC1, which is then phosphorylated and binds either GRB2:SOS1 (Barber et al. 1997) or GRB2:VAV1 (Hanazono et al. 1996). SOS1 and phosphorylated VAV1 catalyze the exchange of GDP for GTP bound to RAS, that is, RAS:GDP is converted to RAS:GTP.

Literature References

PubMed ID	Title	Journal	Year
25887776	Emerging EPO and EPO receptor regulators and signal transducers Kuhrt, D, Wojchowski, DM	Blood	2015
8978277	Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells Barber, DL, Corless, CN, Xia, K, Roberts, TM, D'Andrea, AD	Blood	1997
8677749	Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells Hanazono, Y, Odai, H, Sasaki, K, Iwamatsu, A, Yazaki, Y, Hirai, H	Acta Haematol.	1996
11443118	CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling Arai, A, Kanda, E, Nosaka, Y, Miyasaka, N, Miura, O	J. Biol. Chem.	2001
9209406	The signal transduction through Grb2/Ash in hematopoietic cells Odai, H, Hanazono, Y, Sasaki, K, Iwamatu, A, Yazaki, Y, Hirai, H	Leukemia	1997
7961995	Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor Miura, Y, Miura, O, Ihle, JN, Aoki, N	J. Biol. Chem.	1994