EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma

Stable Identifier
R-HSA-9027373
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
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PLCG2 (PLCgamma2) binds phosphotyrosine-432 and phosphotyrosine-480 of EPOR (Montoye et al. 2005, and inferred from moue homologs). PLCG1 can also bind the phosphorylated EPOR (inferred from mouse homologs). After binding, PLCG2 is phosphorylated (Ren et al. 1994)
Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Shimizu, R, Miura, Y, Okada, K, Komatsu, N

J. Biol. Chem. 1994
15644415 A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Lemmens, I, Eyckerman, S, Catteeuw, D, Tavernier, J, Montoye, T

Blood 2005
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Inferred From
Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2 (Mus musculus)
Authored
May, B  (2017-10-30)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-11-01)
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