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ESRs:STRN:ESTG [cytosol]
Stable Identifier
R-HSA-9027648
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
ESR-associated SRC autophosphorylates (Homo sapiens)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESTG binding induces ESR depalmitoylation (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
G-proteins dissociate from plasma-membrane estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
Membrane estrogen receptors bind SRC (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
PI3K binds membrane-associated estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG [cytosol] (Homo sapiens)
Participants
components
2 x
ESRs [cytosol] (Homo sapiens)
2 x
ESTG [cytosol]
2 x
STRN [cytosol] (Homo sapiens)
Participant Of
output
ESTG binding induces ESR depalmitoylation
G-proteins dissociate from plasma-membrane estrogen receptors
input
Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG
Membrane estrogen receptors bind SRC
hasComponent
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane]
ESRs:STRN:ESTG:MyrG-SRC [plasma membrane]
ESTG:ESRs:STRN:heterotrimeric G(i) protein [plasma membrane]
Inferred To
ESRs:STRN:ESTG [cytosol] (Bos taurus)
ESRs:STRN:ESTG [cytosol] (Caenorhabditis elegans)
ESRs:STRN:ESTG [cytosol] (Canis familiaris)
ESRs:STRN:ESTG [cytosol] (Danio rerio)
ESRs:STRN:ESTG [cytosol] (Drosophila melanogaster)
ESRs:STRN:ESTG [cytosol] (Gallus gallus)
ESRs:STRN:ESTG [cytosol] (Mus musculus)
ESRs:STRN:ESTG [cytosol] (Rattus norvegicus)
ESRs:STRN:ESTG [cytosol] (Sus scrofa)
ESRs:STRN:ESTG [cytosol] (Xenopus tropicalis)
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