PTGS2 dimer oxidises EPA to PGH3

Stable Identifier
R-HSA-9028255
Type
Reaction [transition]
Species
Homo sapiens
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In the absence of aspirin, dimeric cyclooxygenase 2 (PTGS2 dimer aka COX2) located on the ER membrane can mediate the oxidation of eicosapentaenoic acid (EPA) to prostaglandin D3 (PGD3) in activated macrophages (Serhan et al. 2002, Groeger et al. 2010, Wada et al. 2007). It is likely that EPA-derived oxo-derivatives are formed in the same way as demonstrated by Fitzpatrick et al. (Fitzpatrick et al. 1983, Shibata et al. 2002). EPA supplementation to mice resulted in enhanced endogenous production of 15-deoxy-PGJ3 (15d-PGJ3), the final deoxy-product of EPA (Lefils-Lacourtablaise et al. 2013).

Literature References
PubMed ID Title Journal Year
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Serhan, CN, Hong, S, Gronert, K, Colgan, SP, Devchand, PR, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
17519235 Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products

Wada, M, DeLong, CJ, Hong, YH, Rieke, CJ, Song, I, Sidhu, RS, Yuan, C, Warnock, M, Schmaier, AH, Yokoyama, C, Smyth, EM, Wilson, SJ, FitzGerald, GA, Garavito, RM, Sui, de X, Regan, JW, Smith, WL

J. Biol. Chem. 2007
20436486 Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

Groeger, AL, Cipollina, C, Cole, MP, Woodcock, SR, Bonacci, G, Rudolph, TK, Rudolph, V, Freeman, BA, Schopfer, FJ

Nat. Chem. Biol. 2010
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Catalyst Activity
Title
arachidonate 15-lipoxygenase activity of PTGS2 dimer [endoplasmic reticulum membrane]
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Orthologous Events
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