Activated NTRK2 signals through PI3K

Stable Identifier
R-HSA-9028335
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Activated NTRK2 signals through PI3K
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Neurotrophin receptor NTRK2 (TRKB), activated by BDNF or NTF4, activates PI3K, resulting in formation of the PIP3 secondary messenger. PIP3 activates AKT signaling, and AKT signaling activates mTOR signaling (Yuen and Mobley 1999, Cao et al. 2013).
Literature References
PubMed ID Title Journal Year
23424281 Impairment of TrkB-PSD-95 signaling in Angelman syndrome

Cao, C, Rioult-Pedotti, MS, Migani, P, Yu, CJ, Tiwari, R, Parang, K, Spaller, MR, Goebel, DJ, Marshall, J

PLoS Biol. 2013
10486198 Early BDNF, NT-3, and NT-4 signaling events

Yuen, EC, Mobley, WC

Exp. Neurol. 1999
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Event Information
Go Biological Process
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (0051897)
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BioModels Database
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-07)
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