Activated NTRK2 recruits PI3K

Stable Identifier
R-HSA-9028505
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Activated NTRK2 (TRKB) receptor co-immunoprecipitates with the PI3K complex (Yuen and Mobley 1999), as well as the adapter protein GAB1 which, in complex with GRB2, is involved in recruitment of the PI3K complex to some receptor tyrosine kinases (Cao et al. 2013). None of the five autophosphorylated tyrosine residues in the C-terminal tail of NTRK2 conform to the GRB2 or PIK3R1 consensus binding site. It is possible that other phosphorylated tyrosine residues of NTRK2 or additional adapter proteins are involved in PI3K recruitment.

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