p-S363,S380,T573 RS6K translocates to the nucleus

Stable Identifier
R-HSA-9029434
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inactive 90 kDa ribosomal S6 kinases (RSKs) can be detected in both the cytosol and the nucleus (Chen et al. 1992). Based on the available experimental evidence, it is most likely that activation of RSKs happens in the vicinity of the plasma membrane and that active RSKs then translocate to the nucleus (Chen et al. 1992, Smith et al. 1999, Richards et al. 2001, Murphy et al. 2002), but there is a possibility that activation of RSKs can also occur in the nucleus (Chen et al. 1992, reviewed in Anjum and Blenis 2012).

Literature References
PubMed ID Title Journal Year
9915826 Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

Smith, JA, Poteet-Smith, CE, Malarkey, K, Sturgill, TW

J. Biol. Chem. 1999
18813292 The RSK family of kinases: emerging roles in cellular signalling

Anjum, R, Blenis, J

Nat Rev Mol Cell Biol 2008
11585927 Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1

Richards, SA, Dreisbach, VC, Murphy, LO, Blenis, J

Mol. Cell. Biol. 2001
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created